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Sun C, Sun Y, Jiang D, Bao G, Zhu X, Xu D, et al

Nevertheless, in this IR conformation, the L1FnIII-2 interaction in the bottom part of the receptor, which is critical for IGF1R activation, seems to become much weaker and is thus unlikely to be functionally important for IR activation

[cited 2025 Jan 20]

While knocking around they cause oxidative or free radical damage